Professor Sherif El-Khamisy,Director/Associate Dean(R & I)
Information about Professor Sherif El-Khamisy at the University of Bradford.
- School of Pharmacy & Medical Sciences
(Faculty of Life Sciences) - Email:
- s.el-khamisy@bradford.ac.uk
- Telephone:
- +44 1274 238458
Biography
Research
I am a pharmacist interested in understanding how cells maintain genomic integrity. I use interdisciplinary approach fusing genetics, cell biology, biochemistry and spectroscopy with clinical expertise. To further strengthen our translational agenda, I recently took up a joint appointment between the University of Sheffield and the University of Bradford to head the Institute of Cancer Therapeutics. My contributions led to discovery of novel genetic pathways, influenced healthcare practice and developed new technologies. My early work demonstrated a role for PARP1 and CK2 during chromosomal single-strand break (SSB) repair (NAR 2003, Cell 2004). I then moved into more translational aspects, which led to the identification, for the first time, of a defect in SSB repair in two human disorders (Nature 2005 and 2006). Following training at St Jude Hospital in the US, I employed mice to demonstrate the importance of SSB repair for organismal function (EMBO J 2007 and Nature Neuroscience 2009). My interest in this area led to a search for novel activities that repair topoisomerase-linked DNA breaks and resulted in the discovery of the enzyme that repairs topoisomerase 2 - mediated DNA damage, TDP2 (Nature 2009). This seminal finding is critical for a broad range of human disease including cancer. I demonstrated that topoisomerase-induced DNA breaks are pathogenic in other disorders (Hum Mol Gent 2010, Nature Genetics 2014, Nature Neuroscience 2017) and identified key posttranslational modifications and functions (Nature Communications 2012, NAR 2012 & 2016 and Cell Reports 2018). I reviewed the importance of topoisomerase-mediated DNA repair (Nature Rev Cancer 2015, Brain 2018) and described how it maintains mitochondrial gene transcription (Science Advances 2017). We uncovered a novel mechanism by which typhoid toxin exhausts the DNA repair machinery (Nature Communications 2019) and identified TEX264 as a novel component of the topoisomerase-mediated DNA repair pathway (Nature Communications 2020).Teaching
Details on teaching interests, highlights and modules are available for Professor Sherif El-Khamisy as follows:
Teaching interests
For lab details please visit: https://www.elkhamisylab.comProfessional activities
Information about education, employment and areas of particular interest for Professor Sherif El-Khamisy is as follows:
Employment
- University of Sheffield - Co-Founder of the Healthy Lifespan institute
- University of Sheffield - Director of Research and Innovation DoMBB
- University of Sussex - Group Leader and Wellcome Trust Fellow
Education
- University of Sussex - PhD
- American university in Cairo - Diploma in Business Administration
- Ain Shams University - Pharm Sciences
- Cairo University - PharmB
Publications
There are 73 publications involving or that are attributed to Professor Sherif El-Khamisy. They are listed as:
- book chapter (2)
- peer reviewed journal (64)
- reviews (7)
Book Chapter
| Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Role of protein linked DNA breaks in cancer | 2017 | Advances in Experimental Medicine and Biology | Advances in Experimental Medicine and Biology | 1007 | 41 - 58 | Allam W.;Ashour M.;Waly A.;El-Khamisy S. | 0065-2598 | DNA repair | 10.1007/978-3-319-60733-7_3 | ||
| Studying TDP1 function in DNA repair | 2018 | Methods in Molecular Biology | Methods in Molecular Biology | 1703 | 173 - 181 | Chiang S.;Liversidge K.;El-Khamisy S. | 1064-3745 | DNA repair | 10.1007/978-1-4939-7459-7_13 |
Peer Reviewed Journal
| Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection. | 2019 | Nature Communications | 10 | Ibler AEM;ElGhazaly M;Naylor KL;Bulgakova NA;F El-Khamisy S;Humphreys D; | 2041-1723 | 10.1038/s41467-019-12064-1 | |||||
| ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells. | 2013 | PLoS ONE | 8 | Alagoz M;Chiang SC;Sharma A;El-Khamisy SF; | 1932-6203 | 10.1371/journal.pone.0058239 | |||||
| TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1. | 2012 | Nucleic Acids Research | 40 | Zeng Z;Sharma A;Ju L;Murai J;Umans L;Vermeire L;Pommier Y;Takeda S;Huylebroeck D;Caldecott KW;El-Khamisy SF; | 1362-4962 | 10.1093/nar/gks622 | |||||
| SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair. | 2012 | Nature Communications | 3 | Hudson JJ;Chiang SC;Wells OS;Rookyard C;El-Khamisy SF; | 2041-1723 | 10.1038/ncomms1739 | |||||
| Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. | 2014 | Analytical Biochemistry | 454 | Walker S;Meisenberg C;Bibby RA;Askwith T;Williams G;Rininsland FH;Pearl LH;Oliver AW;El-Khamisy S;Ward S;Atack JR; | 1096-0309 | 10.1016/j.ab.2014.03.004 | |||||
| DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1. | 2007 | Neuroscience | 145 | El-Khamisy SF;Caldecott KW; | 0306-4522 | 10.1016/j.neuroscience.2006.08.048 | |||||
| TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. | 2011 | Journal of Biological Chemistry | 286 | Zeng Z;Cortés-Ledesma F;El Khamisy SF;Caldecott KW; | 1083-351X | 10.1074/jbc.M110.181016 | |||||
| TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage. | 2010 | Cell Cycle | 9 | Chiang SC;Carroll J;El-Khamisy SF; | 1551-4005 | 10.4161/cc.9.3.10598 | |||||
| Building Bridges through Science. | 2017 | Neuron | 96 | Lissek T;Adams M;Adelman J;Ahissar E;Akaaboune M;Akil H;al'Absi M;Arain F;Arango-Lasprilla JC;Atasoy D;Avila J;Badawi A;Bading H;Baig AM;Baleriola J;Belmonte C;Bertocchi I;Betz H;Blakemore C;Blanke O;Boehm-Sturm P;Bonhoeffer T;Bonifazi P;Brose N;Campolongo P;Celikel T;Chang CC;Chang TY;Citri A;Cline HT;Cortes JM;Cullen K;Dean K;Delgado-Garcia JM;Desroches M;Disterhoft JF;Dowling JE;Draguhn A;El-Khamisy SF;El Manira A;Enam SA;Encinas JM;Erramuzpe A;Esteban JA;Fariñas I;Fischer E;Fukunaga I;Gabilondo I;Ganten D;Gidon A;Gomez-Esteban JC;Greengard P;Grinevich V;Gruart A;Guillemin R;Hariri AR;Hassan B;Häusser M;Hayashi Y;Hussain NK;Jabbar AA;Jaber M;Jahn R;Janahi EM;Kabbaj M;Kettenmann H;Kindt M;Knafo S;Köhr G;Komai S;Krugers H;Kuhn B;Ghazal NL;Larkum ME;London M;Lutz B;Matute C;Martinez-Millan L;Maroun M;McGaugh J;Moustafa AA;Nasim A;Nave KA;Neher E;Nikolich K;Outeiro T;Palmer LM;Penagarikano O;Perez-Otano I;Pfaff DW;Poucet B;Rahman AU;Ramos-Cabrer P;Rashidy-Pour A;Roberts RJ;Rodrigues S;Sanes JR;Schaefer AT;Segal M;Segev I;Shafqat S;Siddiqui NA;Soreq H;Soriano-García E;Spanagel R;Sprengel R;Stuart G;Südhof TC;Tønnesen J;Treviño M;Uthman BM;Venter JC;Verkhratsky A;Weiss C;Wiesel TN;Yaksi E;Yizhar O;Young LJ;Young P;Zawia NH;Zugaza JL;Hasan MT; | 1097-4199 | 10.1016/j.neuron.2017.09.028 | |||||
| To live or to die: a matter of processing damaged DNA termini in neurons. | 2011 | EMBO Molecular Medicine | 3 | El-Khamisy SF; | 1757-4684 | 10.1002/emmm.201000114 | |||||
| A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. | 2009 | Nature | 461 | Cortes Ledesma F;El Khamisy SF;Zuma MC;Osborn K;Caldecott KW; | 1476-4687 | 10.1038/nature08444 | |||||
| Short-patch single-strand break repair in ataxia oculomotor apraxia-1. | 2009 | Biochemical Society Transactions | 37 | Reynolds JJ;El-Khamisy SF;Caldecott KW; | 1470-8752 | 10.1042/BST0370577 | |||||
| Studying TDP1 Function in DNA Repair. | 2018 | Methods in molecular biology (Clifton, N.J.) | 1703 | Chiang SC;Liversidge K;El-Khamisy SF; | 1940-6029 | 10.1007/978-1-4939-7459-7_13 | |||||
| Recent advances in stem cells therapy: A focus on cancer, Parkinson's and Alzheimer's. | 2018 | Genetic Engineering and Biotechnology Journal | 16 | Fleifel D;Rahmoon MA;AlOkda A;Nasr M;Elserafy M;El-Khamisy SF; | 2090-5920 | 10.1016/j.jgeb.2018.09.002 | |||||
| Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia. | 2018 | Brain | 141 | Walker C;El-Khamisy SF; | 1460-2156 | 10.1093/brain/awy076 | |||||
| TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks. | 2007 | DNA Repair | 6 | El-Khamisy SF;Hartsuiker E;Caldecott KW; | 1568-7864 | 10.1016/j.dnarep.2007.04.015 | |||||
| TDP1-dependent DNA single-strand break repair and neurodegeneration. | 2006 | Mutagenesis | 21 | El-Khamisy SF;Caldecott KW; | 0267-8357 | 10.1093/mutage/gel024 | |||||
| UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. | 2018 | Cell Reports | 23 | Liao C;Beveridge R;Hudson JJR;Parker JD;Chiang SC;Ray S;Ashour ME;Sudbery I;Dickman MJ;El-Khamisy SF; | 2211-1247 | 10.1016/j.celrep.2018.05.033 | |||||
| Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1. | 2016 | Scientific Reports | 6 | Elsayed W;El-Shafie L;Hassan MK;Farag MA;El-Khamisy SF; | 2045-2322 | 10.1038/srep26626 | |||||
| Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. | 2005 | Nature | 434 | El-Khamisy SF;Saifi GM;Weinfeld M;Johansson F;Helleday T;Lupski JR;Caldecott KW; | 1476-4687 | 10.1038/nature03314 | |||||
| The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks | 2004 | Cell | 117 | 17 - 28 | Loizou J.;El-Khamisy S.;Zlatanou A.;Moore D.;Chan D.;Qin J.;Sarno S.;Meggio F.;Pinna L.;Caldecott K. | 0092-8674 | 10.1016/S0092-8674(04)00206-5 | ||||
| SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits. | 2017 | Nature Communications | 8 | Hautbergue GM;Castelli LM;Ferraiuolo L;Sanchez-Martinez A;Cooper-Knock J;Higginbottom A;Lin YH;Bauer CS;Dodd JE;Myszczynska MA;Alam SM;Garneret P;Chandran JS;Karyka E;Stopford MJ;Smith EF;Kirby J;Meyer K;Kaspar BK;Isaacs AM;El-Khamisy SF;De Vos KJ;Ning K;Azzouz M;Whitworth AJ;Shaw PJ; | 2041-1723 | 10.1038/ncomms16063 | |||||
| DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms. | 2019 | DNA Repair | 81 | Abugable AA;Morris JLM;Palminha NM;Zaksauskaite R;Ray S;El-Khamisy SF; | 1568-7856 | 10.1016/j.dnarep.2019.102669 | |||||
| Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. | 2015 | Human Molecular Genetics | 24 | Carroll J;Page TK;Chiang SC;Kalmar B;Bode D;Greensmith L;Mckinnon PJ;Thorpe JR;Hafezparast M;El-Khamisy SF; | 1460-2083 | 10.1093/hmg/ddu500 | |||||
| Measurement of Chromosomal DNA Single-Strand Breaks and Replication Fork Progression Rates | 2006 | Methods in Enzymology | 409 | 410 - 425 | Breslin C.;Clements P.;El-Khamisy S.;Petermann E.;Iles N.;Caldecott K. | 0076-6879 | 10.1016/S0076-6879(05)09024-5 | ||||
| Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs. | 2018 | Ebiomedicine | 35 | Hegazy MT;Allam WR;Hussein MA;Zoheir N;Quartuccio L;El-Khamisy SF;Ragab G; ; | 2352-3964 | 10.1016/j.ebiom.2018.08.007 | |||||
| Gold nanoparticles - an optical biosensor for RNA quantification for cancer and neurologic disorders diagnosis. | 2018 | International journal of nanomedicine | 13 | Shawky SM;Awad AM;Abugable AA;El-Khamisy SF; | 1178-2013 | 10.2147/IJN.S181732 | |||||
| APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. | 2007 | Molecular and Cellular Biology | 27 | Iles N;Rulten S;El-Khamisy SF;Caldecott KW; | 0270-7306 | 10.1128/MCB.02269-06 | |||||
| Rad5, HLTF, and SHPRH: A Fresh View of an Old Story. | 2018 | Trends in Genetics | 34 | Elserafy M;Abugable AA;Atteya R;El-Khamisy SF; | 0168-9525 | 10.1016/j.tig.2018.04.006 | |||||
| Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin. | 2017 | Mechanisms of Ageing and Development | 161 | Atteya R;Ashour ME;Ibrahim EE;Farag MA;El-Khamisy SF; | 1872-6216 | 10.1016/j.mad.2016.04.012 | |||||
| UVA-induced carbon-centred radicals in lightly pigmented cells detected using ESR spectroscopy. | 2018 | Free Radical Biology and Medicine | 126 | Kassouf N;Kay CWM;Volkov A;Chiang SC;Birch-Machin MA;El-Khamisy SF;Haywood RM; | 1873-4596 | 10.1016/j.freeradbiomed.2018.07.019 | |||||
| Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets. | 2012 | British Journal of Cancer | 106 | Gilbert DC;Chalmers AJ;El-Khamisy SF; | 1532-1827 | 10.1038/bjc.2011.498 | |||||
| Choose your yeast strain carefully: the RAD5 gene matters. | 2018 | Nature Reviews Molecular Cell Biology | 19 | Elserafy M;El-Khamisy SF; | 1471-0080 | 10.1038/s41580-018-0005-2 | |||||
| miR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2. | 2018 | Oncotarget | 9 | Mohamed Z;Hassan MK;Okasha S;Mitamura T;Keshk S;Konno Y;Kato T;El-Khamisy SF;Ohba Y;Watari H; | 1949-2553 | 10.18632/oncotarget.25698 | |||||
| Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism. | 2017 | Advances in Experimental Medicine and Biology | 1007 | Abugable AA;Awwad DA;Fleifel D;Ali MM;El-Khamisy S;Elserafy M; | 0065-2598 | 10.1007/978-3-319-60733-7_9 | |||||
| Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits. | 2017 | Disease models & mechanisms | 10 | Herranz-Martin S;Chandran J;Lewis K;Mulcahy P;Higginbottom A;Walker C;Valenzuela IMY;Jones RA;Coldicott I;Iannitti T;Akaaboune M;El-Khamisy SF;Gillingwater TH;Shaw PJ;Azzouz M; | 1754-8411 | 10.1242/dmm.029892 | |||||
| A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. | 2016 | Cell Reports | 15 | Mazouzi A;Stukalov A;Müller AC;Chen D;Wiedner M;Prochazkova J;Chiang SC;Schuster M;Breitwieser FP;Pichlmair A;El-Khamisy SF;Bock C;Kralovics R;Colinge J;Bennett KL;Loizou JI; | 2211-1247 | 10.1016/j.celrep.2016.03.077 | |||||
| Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks. | 2010 | Human Molecular Genetics | 19 | Kerzendorfer C;Whibley A;Carpenter G;Outwin E;Chiang SC;Turner G;Schwartz C;El-Khamisy S;Raymond FL;O'Driscoll M; | 1460-2083 | 10.1093/hmg/ddq008 | |||||
| A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. | 2003 | Nucleic Acids Research | 31 | El-Khamisy SF;Masutani M;Suzuki H;Caldecott KW; | 1362-4962 | 10.1093/nar/gkg761 | |||||
| Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. | 2017 | Nucleic Acids Research | 45 | Meisenberg C;Ashour ME;El-Shafie L;Liao C;Hodgson A;Pilborough A;Khurram SA;Downs JA;Ward SE;El-Khamisy SF; | 1362-4962 | 10.1093/nar/gkw1026 | |||||
| Topoisomerase-mediated chromosomal break repair: an emerging player in many games. | 2015 | Nature Reviews. Cancer | 15 | Ashour ME;Atteya R;El-Khamisy SF; | 1474-1768 | 10.1038/nrc3892 | |||||
| Gold aggregating gold: A novel nanoparticle biosensor approach for the direct quantification of hepatitis C virus RNA in clinical samples. | 2017 | Biosensors and Bioelectronics | 92 | Shawky SM;Awad AM;Allam W;Alkordi MH;El-Khamisy SF; | 1873-4235 | 10.1016/j.bios.2016.11.001 | |||||
| Competing endogenous RNA network crosstalk reveals novel molecular markers in colorectal cancer. | 2018 | Journal of Cellular Biochemistry | 119 | Samir N;Matboli M;El-Tayeb H;El-Tawdi A;Hassan MK;Waly A;El-Akkad HAE;Ramadan MG;Al-Belkini TN;El-Khamisy S;El-Asmar F; | 1097-4644 | 10.1002/jcb.26884 | |||||
| Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan. | 2015 | Molecular Cancer Therapeutics | 14 | Meisenberg C;Gilbert DC;Chalmers A;Haley V;Gollins S;Ward SE;El-Khamisy SF; | 1538-8514 | 10.1158/1535-7163.MCT-14-0762 | |||||
| Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage. | 2017 | Science Advances | 3 | Chiang SC;Meagher M;Kassouf N;Hafezparast M;McKinnon PJ;Haywood R;El-Khamisy SF; | 2375-2548 | 10.1126/sciadv.1602506 | |||||
| C9orf72 expansion disrupts ATM-mediated chromosomal break repair. | 2017 | Nature Neuroscience | 20 | Walker C;Herranz-Martin S;Karyka E;Liao C;Lewis K;Elsayed W;Lukashchuk V;Chiang SC;Ray S;Mulcahy PJ;Jurga M;Tsagakis I;Iannitti T;Chandran J;Coldicott I;De Vos KJ;Hassan MK;Higginbottom A;Shaw PJ;Hautbergue GM;Azzouz M;El-Khamisy SF; | 1546-1726 | 10.1038/nn.4604 | |||||
| Study of the mechanisms of crocetin-induced differentiation and apoptosis in human acute promyelocytic leukemia cells. | 2018 | Journal of Cellular Biochemistry | Moradzadeh M;Ghorbani A;Erfanian S;Mohaddes ST;Rahimi H;Karimiani EG;Mashkani B;Chiang SC;El-Khamisy SF;Tabarraei A;Sadeghnia HR; | 1097-4644 | 10.1002/jcb.27489 | ||||||
| Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites. | 2012 | BIOCHIMIE | 94 | Lebedeva NA;Rechkunova NI;El-Khamisy SF;Lavrik OI; | 1638-6183 | 10.1016/j.biochi.2012.04.004 | |||||
| Role of Protein Linked DNA Breaks in Cancer. | 2017 | Advances in Experimental Medicine and Biology | 1007 | Allam WR;Ashour ME;Waly AA;El-Khamisy S; | 0065-2598 | 10.1007/978-3-319-60733-7_3 | |||||
| DNA repair and resistance to topoisomerase I inhibitors: mechanisms, biomarkers and therapeutic targets. | 2012 | Current Medicinal Chemistry | 19 | Alagoz M;Gilbert DC;El-Khamisy S;Chalmers AJ; | 1875-533X | 10.2174/092986712802002590 | |||||
| The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. | 2006 | Nature | 443 | Ahel I;Rass U;El-Khamisy SF;Katyal S;Clements PM;McKinnon PJ;Caldecott KW;West SC; | 1476-4687 | 10.1038/nature05164 | |||||
| The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. | 2009 | Nature Neuroscience | 12 | Lee Y;Katyal S;Li Y;El-Khamisy SF;Russell HR;Caldecott KW;McKinnon PJ; | 1546-1726 | 10.1038/nn.2375 | |||||
| Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia | 2009 | Molecular and Cellular Biology | 29 | 1354 - 1362 | Reynolds J.;El-Khamisy S.;Katyal S.;Clements P.;McKinnon P.;Caldecott K. | 0270-7306 | 10.1128/MCB.01471-08 | ||||
| TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. | 2007 | EMBO Journal | 26 | Katyal S;el-Khamisy SF;Russell HR;Li Y;Ju L;Caldecott KW;McKinnon PJ; | 1460-2075 | 10.1038/sj.emboj.7601869 | |||||
| Nucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis. | 2019 | Biosensors and Bioelectronics | 141 | Osman DI;El-Sheikh SM;Sheta SM;Ali OI;Salem AM;Shousha WG;El-Khamisy SF;Shawky SM; | 1873-4235 | 10.1016/j.bios.2019.111451 | |||||
| A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3. | 2018 | Redox Biology | 18 | Southam HM;Smith TW;Lyon RL;Liao C;Trevitt CR;Middlemiss LA;Cox FL;Chapman JA;El-Khamisy SF;Hippler M;Williamson MP;Henderson PJF;Poole RK; | 2213-2317 | 10.1016/j.redox.2018.06.008 | |||||
| Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. | 2009 | DNA Repair | 8 | El-Khamisy SF;Katyal S;Patel P;Ju L;McKinnon PJ;Caldecott KW; | 1568-7864 | 10.1016/j.dnarep.2009.02.002 | |||||
| Nucleosides Rescue Replication-Mediated Genome Instability of Human Pluripotent Stem Cells. | 2020 | Stem Cell Reports | 14 | Halliwell JA;Frith TJR;Laing O;Price CJ;Bower OJ;Stavish D;Gokhale PJ;Hewitt Z;El-Khamisy SF;Barbaric I;Andrews PW; | 2213-6711 | 10.1016/j.stemcr.2020.04.004 | |||||
| Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish. | 2020 | Oncotarget | 11 | Kim HR;Santhakumar K;Markham E;Baldera D;Greenald D;Bryant HE;El-Khamisy SF;van Eeden FJ; | 1949-2553 | 10.18632/oncotarget.27521 | |||||
| TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan. | 2014 | Journal of Cancer Science and Therapy | 6 | Meisenberg C;Ward SE;Schmid P;El-Khamisy SF; | 1948-5956 | 10.4172/1948-5956.1000280 | |||||
| TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. | 2020 | Nature Communications | 11 | Fielden J;Wiseman K;Torrecilla I;Li S;Hume S;Chiang SC;Ruggiano A;Narayan Singh A;Freire R;Hassanieh S;Domingo E;Vendrell I;Fischer R;Kessler BM;Maughan TS;El-Khamisy SF;Ramadan K; | 2041-1723 | 10.1038/s41467-020-15000-w | |||||
| P18/Stathmin1 is regulated by miR-31 in ovarian cancer in response to taxane. | 2015 | ONCOSCIENCE | 2 | Hassan MK;Watari H;Mitamura T;Mohamed Z;El-Khamisy SF;Ohba Y;Sakuragi N; | 2331-4737 | 10.18632/oncoscience.143 | |||||
| TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. | 2014 | Nature Genetics | 46 | Gómez-Herreros F;Schuurs-Hoeijmakers JH;McCormack M;Greally MT;Rulten S;Romero-Granados R;Counihan TJ;Chaila E;Conroy J;Ennis S;Delanty N;Cortés-Ledesma F;de Brouwer AP;Cavalleri GL;El-Khamisy SF;de Vries BB;Caldecott KW; | 1546-1718 | 10.1038/ng.2929 | |||||
| TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy. | 2014 | Nucleic Acids Research | 42 | Alagoz M;Wells OS;El-Khamisy SF; | 1362-4962 | 10.1093/nar/gkt1260 |
Reviews
| Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Nucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis | 2019 | Biosensors and Bioelectronics | 141 | Osman D.I.;El-Sheikh S.M.;Sheta S.M.;Ali O.I.;Salem A.M.;Shousha W.G.;EL-Khamisy S.F.;Shawky S.M. | 0956-5663 | 10.1016/j.bios.2019.111451 | |||||
| Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia | 2018 | Brain | 141 | 1247 - 1262 | Walker C.;El-Khamisy S. | 0006-8950 | 10.1093/brain/awy076 | ||||
| DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1 | 2007 | Neuroscience | 145 | 1260 - 1266 | El-Khamisy S.;Caldecott K. | 0306-4522 | 10.1016/j.neuroscience.2006.08.048 | ||||
| To live or to die: A matter of processing damaged DNA termini in neurons | 2011 | EMBO Molecular Medicine | 3 | 78 - 88 | El-Khamisy S. | 1757-4676 | 10.1002/emmm.201000114 | ||||
| DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms | 2019 | DNA Repair | 81 | Abugable A.A.;Morris J.L.M.;Palminha N.M.;Zaksauskaite R.;Ray S.;El-Khamisy S.F. | 1568-7864 | 10.1016/j.dnarep.2019.102669 | |||||
| TDP1-dependent DNA single-strand break repair and neurodegeneration | 2006 | Mutagenesis | 21 | 219 - 224 | El-Khamisy S.;Caldecott K. | 0267-8357 | 10.1093/mutage/gel024 | ||||
| Topoisomerase i inhibition in colorectal cancer: Biomarkers and therapeutic targets | 2012 | British Journal of Cancer | 106 | 18 - 24 | Gilbert D.;Chalmers A.;El-Khamisy S. | 0007-0920 | 10.1038/bjc.2011.498 |