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Association of bisphenol A with 25(OH)D, 1,25(OH)2D levels and 1,25(OH)2D/25(OH)D ratio in cord blood

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Abstract

The aim was to investigate the association between bisphenol A (BPA), 25-hydroxy vitamin D [25(OH)D], and 1α,25 dihydroxy vitamin D [1,25(OH)2D] levels in the cord blood of newborn babies. BPA was measured by high pressure liquid chromatography (HPLC) and vitamin D levels by commercial ELISA or ECLIA kits. BPA and Vitamin D levels were grouped according to tertile values. In the cord blood, the median 25(OH)D level was 14.9 ng/mL (IQR: 8.5–20.8) and median 1,25(OH)2D level was 53.3 pg/dL (IQR: 42.3–98.4). 25(OH)D levels were < 20 ng/mL in 76.5% of the babies. BPA was detectable in 72.4% of the cord blood samples; median BPA level was 1.57 ng/mL (IQR: < DL-4.05 ng/mL). Frequencies of vitamin D deficiency and frequencies of cases having the highest tertile active vitamin D levels were similar in groups of BPA tertiles in both univariate and multivariate analysis. In conclusion, both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns. Bisphenol A levels were not correlated with vitamin D levels in cord blood of healthy mother-fetus pairs.

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Data availability

Data can be requested from corresponding author (siyalcin@hacettepe.edu.tr).

Abbreviations

BPA:

Bisphenol A

25(OH)D:

25-Hydroxy vitamin D

1,25(OH)2D:

1α,25 Dihydroxy vitamin D

ELISA:

Enzyme linked immunosorbent assay

ECLIA:

Electrochemiluminescence immunoassay

VDBP:

Vitamin D binding protein

HRP:

Horseradish peroxidase

HPLC:

High performance liquid chromatography

LOD:

Limit of detection

LOQ:

Limit of quantification

LGA:

Large for gestational age

BMI:

Body mass index

OR:

Odds ratio

CI:

Confidence intervals

ER:

Estrogen receptor

NHANES:

The National Health and Nutrition Examination Survey

DEHP:

Di(2-ethylhexyl) phthalate

PCOS:

Polycystic ovary syndrome

OSAS:

Obstructive Sleep Apnea Syndrome

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Acknowledgements

Dr. Yurdakök was the thesis advisor and passed away after the article of this study was written.

Funding

Hacettepe University Scientific Research Projects Coordination Unit; THD-2020–18332, Turkey.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Etlik Zübeyde Hanım Women’s Health Teaching and Research Hospital, Ankara, Turkey

    Fatma Pınar TABANLI

  2. Department of Social Pediatrics, Institute of Child Health, Hacettepe University, Ankara, Turkey

    Fatma Pınar TABANLI, Sıddika Songül YALÇIN & Kadriye YURDAKÖK

  3. Department of Pediatrics, Social Pediatrics Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Sıddika Songül YALÇIN & Kadriye YURDAKÖK

  4. Department of Gynecology and Obstetrics, Guven Hospital, Ankara, Turkey

    Sedef RAMOĞLU & Şadıman KIYKAÇ ALTINBAŞ

  5. Department of Pharmaceutical Toxicology, Hacettepe University Faculty of Pharmacy, Ankara, Turkey

    Anıl YİRÜN & Pınar ERKEKOĞLU

  6. Department of Pharmaceutical Toxicology, Çukurova University Faculty of Pharmacy, Adana, Turkey

    Anıl YİRÜN

  7. Department of Pharmaceutical Toxicology, Bahçeşehir University School of Pharmacy, Istanbul, Turkey

    Aylin BALCI ÖZYURT

  8. Department of Biochemistry, Etlik Zübeyde Hanım Women’s Health Teaching and Research Hospital, Ankara, Turkey

    Funda GÜÇEL

Authors
  1. Fatma Pınar TABANLI
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  2. Sıddika Songül YALÇIN
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  3. Sedef RAMOĞLU
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Contributions

KY and FPT contributed to the conception and design of the work. FPT and KY contributed to the acquisition of data. ŞKA and SR received cord blood from mothers in the obstetrics clinic. ÜPE, AY, ABO and FG performed laboratory analysis. SSY and FPT contributed to the statistical analysis and interpretation of data for the work. FPT prepared the draft of the manuscript. KY, SSY and FPT wrote the final manuscript. PE corrected the final manuscript. All authors gave final approval and agree to be accountable for all aspects of work ensuring integrity and accuracy.

Corresponding author

Correspondence to Sıddika Songül YALÇIN.

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Ethical approval

Hacettepe University Ethics Committee approved the study protocol (GO-19/701). All methods were carried out in accordance with relevant guidelines and regulations along with ethical approval statement and informed consent to participation. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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All mothers were informed of the research and an informed written consent to participate was obtained from all of the participants.

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The authors have no relevant financial or non-financial interests to disclose.

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TABANLI, F.P., YALÇIN, S.S., RAMOĞLU, S. et al. Association of bisphenol A with 25(OH)D, 1,25(OH)2D levels and 1,25(OH)2D/25(OH)D ratio in cord blood. Environ Sci Pollut Res 30, 100391–100402 (2023). https://doi.org/10.1007/s11356-023-29288-w

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