Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification

Folkert Kuipers; Jan Freark de Boer; Bart Staels

doi:10.1016/j.cmet.2020.02.006

Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification

Cell Metab. 2020 Mar 3;31(3):445-447. doi: 10.1016/j.cmet.2020.02.006.

Authors

Folkert Kuipers¹, Jan Freark de Boer², Bart Staels³

Affiliations

¹ Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands. Electronic address: f.kuipers@umcg.nl.
² Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands.
³ Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, 59000 Lille, France.

PMID: 32130878
DOI: 10.1016/j.cmet.2020.02.006

Abstract

The microbiome is well known to influence the immune response of the host. Song et al. now show that the microbiome modulates adaptive immunity in mice through formation of bile acid species acting on RORγ⁺ regulatory T cells via the Vitamin D Receptor, thereby lowering the vulnerability for chemically induced colitis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adaptive Immunity
Animals
Bile
Gastrointestinal Microbiome*
Homeostasis
Mice
Microbiota*
Nuclear Receptor Subfamily 1, Group F, Member 3
T-Lymphocytes, Regulatory

Substances

Nuclear Receptor Subfamily 1, Group F, Member 3