Eighteen months into COVID-19, the pandemic continues to cause uncertainty and threatens progress on HIV and other global health areas. COVID-19 has exposed the inadequacy of investments and profound inequities in public health. At the same time, COVID-19 has benefitted from four decades of HIV experience as witnessed by the rapid development of COVID-19 vaccines. The pandemic has also opened doors to new possibilities for HIV science and service delivery. In the panel discussion, leading experts will discuss the impact of COVID-19 disruptions on HIV and how the HIV response can seize the momentum generated by COVID-19.