My Bibliography

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Eken JA, Koning MT, Kupcova K, Sepúlveda Yáñez JH, de Groen RAL, Quinten E, Janssen J, van Bergen CAM, Vermaat JSP, Cleven A, Navarrete MA, Ylstra B, de Jong D, Havranek O, Jumaa H, Veelken H. Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL. J Exp Med. 2024 May 6;221(5). doi: 10.1084/jem.20230941. Epub 2024 Mar 21. PubMed PMID: 38512136; PubMed Central PMCID: PMC10959178.

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Zemankova P, Cerna M, Horackova K, Ernst C, Soukupova J, Borecka M, Blümcke B, Cerna L, Cerna M, Curtisova V, Dolezalova T, Duskova P, Dvorakova L, Foretova L, Havranek O, Hauke J, Hahnen E, Hodulova M, Hovhannisyan M, Hruskova L, Janatova M, Janikova M, Jelinkova S, Just P, Kosarova M, Koudova M, Krutilkova V, Machackova E, Matejkova K, Michalovska R, Misove A, Nehasil P, Nemcova B, Novotny J, Panczak A, Pesek P, Scheinost O, Springer D, Stastna B, Stranecky V, Subrt I, Tavandzis S, Tureckova E, Vesela K, Vlckova Z, Vocka M, Wappenschmidt B, Zima T, Kleibl Z, Kleiblova P. A deep intronic recurrent CHEK2 variant c.1009-118_1009-87delinsC affects pre-mRNA splicing and contributes to hereditary breast cancer predisposition. Breast. 2024 Mar 25;75:103721. doi: 10.1016/j.breast.2024.103721. [Epub ahead of print] PubMed PMID: 38554551; PubMed Central PMCID: PMC10998186.

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Malarikova D, Jorda R, Kupcova K, Senavova J, Dolnikova A, Pokorna E, Kazantsev D, Nozickova K, Sovilj D, Bellanger C, Chiron D, Andera L, Krystof V, Strnad M, Helman K, Klanova M, Trneny M, Havranek O, Klener P. Cyclin dependent kinase 4/6 inhibitor palbociclib synergizes with BCL2 inhibitor venetoclax in experimental models of mantle cell lymphoma without RB1 deletion. Exp Hematol Oncol. 2024 Mar 25;13(1):34. doi: 10.1186/s40164-024-00499-2. PubMed PMID: 38528594; PubMed Central PMCID: PMC10962182.

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Tkachenko A, Havranek O. Erythronecroptosis: an overview of necroptosis or programmed necrosis in red blood cells. Mol Cell Biochem. 2024 Mar 1;. doi: 10.1007/s11010-024-04948-8. [Epub ahead of print] Review. PubMed PMID: 38427167.

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Tkachenko A, Kupcova K, Havranek O. B-Cell Receptor Signaling and Beyond: The Role of Igα (CD79a)/Igβ (CD79b) in Normal and Malignant B Cells. Int J Mol Sci. 2023 Dec 19;25(1). doi: 10.3390/ijms25010010. Review. PubMed PMID: 38203179; PubMed Central PMCID: PMC10779339.

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Kral J, Jelinkova S, Zemankova P, Vocka M, Borecka M, Cerna L, Cerna M, Dostalek L, Duskova P, Foretova L, Havranek O, Horackova K, Hovhannisyan M, Chvojka S, Kalousova M, Kosarova M, Koudova M, Krutilkova V, Machackova E, Nehasil P, Novotny J, Otahalova B, Puchmajerova A, Safarikova M, Slama J, Stranecky V, Subrt I, Tavandzis S, Zikan M, Zima T, Soukupova J, Kleiblova P, Kleibl Z, Janatova M. Germline multigene panel testing of patients with endometrial cancer. Oncol Lett. 2023 Jun;25(6):216. doi: 10.3892/ol.2023.13802. eCollection 2023 Jun. PubMed PMID: 37153042; PubMed Central PMCID: PMC10157349.

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Tkachenko A, Onishchenko A, Myasoedov V, Yefimova S, Havranek O. Assessing regulated cell death modalities as an efficient tool for in vitro nanotoxicity screening: a review. Nanotoxicology. 2023 Apr;17(3):218-248. doi: 10.1080/17435390.2023.2203239. Epub 2023 Apr 21. Review. PubMed PMID: 37083543.

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Tkachenko A, Havránek O. Redox Status of Erythrocytes as an Important Factor in Eryptosis and Erythronecroptosis. Folia Biol (Praha). 2023;69(4):116-126. doi: 10.14712/fb2023069040116. PubMed PMID: 38410969.

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Maco M, Kupcova K, Herman V, Ondeckova I, Kozak T, Mocikova H, Havranek O. Circulating tumor DNA in Hodgkin lymphoma. Ann Hematol. 2022 Nov;101(11):2393-2403. doi: 10.1007/s00277-022-04949-x. Epub 2022 Sep 8. Review. PubMed PMID: 36074181; PubMed Central PMCID: PMC9546971.

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Henderson J, Havranek O, Ma MCJ, Herman V, Kupcova K, Chrbolkova T, Pacheco-Blanco M, Wang Z, Comer JM, Zal T, Davis RE. Detecting Förster resonance energy transfer in living cells by conventional and spectral flow cytometry. Cytometry A. 2022 Oct;101(10):818-834. doi: 10.1002/cyto.a.24472. Epub 2021 Jun 24. PubMed PMID: 34128311.

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Klanova M, Kazantsev D, Pokorna E, Zikmund T, Karolova J, Behounek M, Renesova N, Sovilj D, Kelemen CD, Helman K, Jaksa R, Havranek O, Andera L, Trneny M, Klener P. Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas. Mol Cancer Ther. 2022 Jan;21(1):89-99. doi: 10.1158/1535-7163.MCT-21-0511. Epub 2021 Nov 2. PubMed PMID: 34728569; PubMed Central PMCID: PMC9398137.

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Szydłowski M, Garbicz F, Jabłońska E, Górniak P, Komar D, Pyrzyńska B, Bojarczuk K, Prochorec-Sobieszek M, Szumera-Ciećkiewicz A, Rymkiewicz G, Cybulska M, Statkiewicz M, Gajewska M, Mikula M, Gołas A, Domagała J, Winiarska M, Graczyk-Jarzynka A, Białopiotrowicz E, Polak A, Barankiewicz J, Puła B, Pawlak M, Nowis D, Golab J, Tomirotti AM, Brzózka K, Pacheco-Blanco M, Kupcova K, Green MR, Havranek O, Chapuy B, Juszczyński P. Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies. Cancer Res. 2021 Dec 1;81(23):6029-6043. doi: 10.1158/0008-5472.CAN-21-1023. Epub 2021 Oct 8. PubMed PMID: 34625423.

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Soukupova J, Zemankova P, Nehasil P, Kleibl Z. Re: ERCC3, a new ovarian cancer susceptibility gene?. Eur J Cancer. 2021 Jun;150:278-280. doi: 10.1016/j.ejca.2021.03.014. Epub 2021 Apr 21. PubMed PMID: 33895055.

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Vockova P, Molinsky J, Klanova M, Karban J, Spacek M, Havranek O, Kupcova K, Kazantsev D, Trneny M, Klener P. CD31/PECAM-1 impacts engraftment, growth and spread of mantle cell lymphoma cells and positively correlates with extramedullary involvement. Leuk Lymphoma. 2021 Apr;62(4):861-867. doi: 10.1080/10428194.2020.1849678. Epub 2020 Nov 25. PubMed PMID: 33238780.

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Jain N, Singh S, Laliotis G, Hart A, Muhowski E, Kupcova K, Chrbolkova T, Khashab T, Chowdhury SM, Sircar A, Shirazi F, Singh RK, Alinari L, Zhu J, Havranek O, Tsichlis P, Woyach J, Baiocchi R, Samaniego F, Sehgal L. Targeting phosphatidylinositol 3 kinase-β and -δ for Bruton tyrosine kinase resistance in diffuse large B-cell lymphoma. Blood Adv. 2020 Sep 22;4(18):4382-4392. doi: 10.1182/bloodadvances.2020001685. PubMed PMID: 32926124; PubMed Central PMCID: PMC7509871.

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Kleiblova P, Stolarova L, Krizova K, Lhota F, Hojny J, Zemankova P, Havranek O, Vocka M, Cerna M, Lhotova K, Borecka M, Janatova M, Soukupova J, Sevcik J, Zimovjanova M, Kotlas J, Panczak A, Vesela K, Cervenkova J, Schneiderova M, Burocziova M, Burdova K, Stranecky V, Foretova L, Machackova E, Tavandzis S, Kmoch S, Macurek L, Kleibl Z. Identification of deleterious germline CHEK2 mutations and their association with breast and ovarian cancer. Int J Cancer. 2019 Oct 1;145(7):1782-1797. doi: 10.1002/ijc.32385. Epub 2019 May 20. PubMed PMID: 31050813.

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Prukova D, Andera L, Nahacka Z, Karolova J, Svaton M, Klanova M, Havranek O, Soukup J, Svobodova K, Zemanova Z, Tuskova D, Pokorna E, Helman K, Forsterova K, Pacheco-Blanco M, Vockova P, Berkova A, Fronkova E, Trneny M, Klener P. Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma. Clin Cancer Res. 2019 Jul 15;25(14):4455-4465. doi: 10.1158/1078-0432.CCR-18-3275. Epub 2019 Apr 19. PubMed PMID: 31004002.

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Kleiblová P, Stolařová L, Křížová K, Lhota F, Hojný J, Zemánková P, Havránek O, Vočka M, Černá M, Lhotová K, Borecká M, Janatová M, Soukupová J, Ševčík J, Zimovjanová M, Kotlas J, Panczak A, Veselá K, Červenková J, Schneiderová M, Burócziová M, Burdová K, Stránecký V, Foretová L, Macháčková E, Tavandzis S, Kmoch S, Macůrek L, Kleibl Z. Germline CHEK2 Gene Mutations in Hereditary Breast Cancer Predisposition - Mutation Types and their Biological and Clinical Relevance. Klin Onkol. 2019 Summer;32(Supplementum2):36-50. doi: 10.14735/amko2019S36. PubMed PMID: 31409080.

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Jain N, Hartert K, Tadros S, Fiskus W, Havranek O, Ma MCJ, Bouska A, Heavican T, Kumar D, Deng Q, Moore D, Pak C, Liu CL, Gentles AJ, Hartmann E, Kridel R, Smedby KE, Juliusson G, Rosenquist R, Gascoyne RD, Rosenwald A, Giancotti F, Neelapu SS, Westin J, Vose JM, Lunning MA, Greiner T, Rodig S, Iqbal J, Alizadeh AA, Davis RE, Bhalla K, Green MR. Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in diffuse large B cell lymphoma. Sci Transl Med. 2019 Jun 19;11(497). doi: 10.1126/scitranslmed.aav5599. PubMed PMID: 31217338; PubMed Central PMCID: PMC6724184.

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Vangapandu HV, Havranek O, Ayres ML, Kaipparettu BA, Balakrishnan K, Wierda WG, Keating MJ, Davis RE, Stellrecht CM, Gandhi V. B-cell Receptor Signaling Regulates Metabolism in Chronic Lymphocytic Leukemia. Mol Cancer Res. 2017 Dec;15(12):1692-1703. doi: 10.1158/1541-7786.MCR-17-0026. Epub 2017 Aug 23. PubMed PMID: 28835371; PubMed Central PMCID: PMC5714317.

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Havranek O, Xu J, Köhrer S, Wang Z, Becker L, Comer JM, Henderson J, Ma W, Man Chun Ma J, Westin JR, Ghosh D, Shinners N, Sun L, Yi AF, Karri AR, Burger JA, Zal T, Davis RE. Tonic B-cell receptor signaling in diffuse large B-cell lymphoma. Blood. 2017 Aug 24;130(8):995-1006. doi: 10.1182/blood-2016-10-747303. Epub 2017 Jun 23. PubMed PMID: 28646116; PubMed Central PMCID: PMC5813722.

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Mathur R, Sehgal L, Havranek O, Köhrer S, Khashab T, Jain N, Burger JA, Neelapu SS, Davis RE, Samaniego F. Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs. Haematologica. 2017 Feb;102(2):373-380. doi: 10.3324/haematol.2016.144964. Epub 2016 Oct 14. PubMed PMID: 27742770; PubMed Central PMCID: PMC5286945.

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Köhrer S, Havranek O, Seyfried F, Hurtz C, Coffey GP, Kim E, Ten Hacken E, Jäger U, Vanura K, O'Brien S, Thomas DA, Kantarjian H, Ghosh D, Wang Z, Zhang M, Ma W, Jumaa H, Debatin KM, Müschen M, Meyer LH, Davis RE, Burger JA. Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition. Leukemia. 2016 Jun;30(6):1246-54. doi: 10.1038/leu.2016.9. Epub 2016 Feb 5. PubMed PMID: 26847027; PubMed Central PMCID: PMC5459356.

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Havranek O, Kleiblova P, Hojny J, Lhota F, Soucek P, Trneny M, Kleibl Z. Association of Germline CHEK2 Gene Variants with Risk and Prognosis of Non-Hodgkin Lymphoma. PLoS One. 2015;10(10):e0140819. doi: 10.1371/journal.pone.0140819. eCollection 2015. PubMed PMID: 26506619; PubMed Central PMCID: PMC4624763.

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Havranek O, Koehrer S, Xu J, Becker L, Commer JE, Karri A, Wang Z, Ma W, Westin JR, Zal T, Burger JA, Davis RE. B-Cell Receptor Signaling in Diffuse Large B-Cell Lymphoma: Tonic Alone in the Germinal Center B-Cell Subtype, plus Self Antigen-Induced in the Activated B-Cell Subtype. American Society of Hematology Annual Meeting. Oral presentation; 2015; Blood 2015 126:464; c2015.

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Havranek O, Koehrer S, Comer JM, Wang Z, Xu J, Ghosh D, Shinners N, Sun L, Ma W, Burger JA, Davis R. The B-Cell Receptor Is Required for Optimal Viability, Growth, and Chemotherapy Resistance of Diffuse Large B-Cell Lymphoma Cell Lines of the Germinal Center B-Cell Subtype. American Society of Hematology Annual Meeting. Oral Presentation; 2014; Blood 124:493; c2014.

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Koehrer S, Havranek O, Davis R, Seyfried F, Coffey GP, Kim E, Rosin NY, Hacken E, Jager U, Vanura K, O'Brien S, Thomas DA, Kantarjian H, Ghosh D, Wang Z, Meyer LH, Jumaa H, Burger JA. Immunoglobulin Heavy Chain (IgH) Knockout Inhibits Proliferation of Pre-BCR+ B-Cell Acute Lymphoblastic Leukemia (B-ALL) Via a FOXO1 and MYC Dependent Mechanism. American Society of Hematology Annual Meeting. Oral Presentation; 2014; Blood 124:287; c2014.

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Havranek O, Westin JR, Zhang M, Rawal S, Kwak LW, Neelapu SS, Davis R. Integrated Analysis of Genomic and Gene Expression Profiles In Follicular Lymphoma Reveals Subsets and Driver Genes Of Potential Micro environmental Importance. American Society of Hematology Annual Meeting; 2013; Blood 122:2487; c2013.

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Havranek O, Spacek M, Hubacek P, Mocikova H, Benesova K, Soucek P, Trneny M, Kleibl Z. No association between the TP53 codon 72 polymorphism and risk or prognosis of Hodgkin and non-Hodgkin lymphoma. Leuk Res. 2011 Aug;35(8):1117-9. doi: 10.1016/j.leukres.2011.04.001. Epub 2011 May 5. PubMed PMID: 21546086.

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Kleibl Z, Havranek O, Kormunda S, Novotny J, Foretova L, Machackova E, Soukupova J, Janatova M, Tavandzis S, Pohlreich P. The AIB1 gene polyglutamine repeat length polymorphism and the risk of breast cancer development. J Cancer Res Clin Oncol. 2011 Feb;137(2):331-8. doi: 10.1007/s00432-010-0889-5. Epub 2010 Apr 27. PubMed PMID: 20422428.

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Havranek O, Spacek M, Hubacek P, Mocikova H, Markova J, Trneny M, Kleibl Z. Alterations of CHEK2 forkhead-associated domain increase the risk of Hodgkin lymphoma. Neoplasma. 2011;58(5):392-5. doi: 10.4149/neo_2011_05_392. PubMed PMID: 21744992.

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Mohelnikova-Duchonova B, Havranek O, Hlavata I, Foretova L, Kleibl Z, Pohlreich P, Soucek P. CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify the risk of sporadic pancreatic cancer. Cancer Epidemiol. 2010 Oct;34(5):656-8. doi: 10.1016/j.canep.2010.06.008. PubMed PMID: 20643596.

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Ticha I, Stribrna J, Soukupova J, Janatova M, Kleibl Z, Havranek O, Pohlreich P. Genomic rearrangements in BRCA1/2 and CHEK2 genes in Czech high-risk breast/ovarian cancer patients. Biennial Congress of the European Association for Cancer Research; 2010; European Journal of Cancer Supplements; 8(5):22; c2010.

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Havranek O, Kleibl Z, Soucek P, Trneny M. Risk of non-Hodgkin lymphoma development in patients carrying mutations in CHEK2 gene or polymorphism R72P in P53 gene. Biennial Congress of the European Association for Cancer Research; 2010; European Journal of Cancer Supplements; 8(5):22; c2010.

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Kleibl Z, Havranek O, Hlavata I, Novotny J, Sevcik J, Pohlreich P, Soucek P. The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population. Eur J Cancer. 2009 Mar;45(4):618-24. doi: 10.1016/j.ejca.2008.09.022. Epub 2008 Nov 6. PubMed PMID: 18996005.

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Havranek O, Kleibl Z, Soucek P, Trneny M. Alterations of CHEK2 gene in non-Hodgkin lymphoma patients. Congress of European Hematology Association; 2009; Haematologica, 94(s2): 273-274, Abstract #0671; c2009.

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Kleibl Z, Havranek O, Novotny J, Kleiblova P, Soucek P, Pohlreich P. Analysis of CHEK2 FHA domain in Czech patients with sporadic breast cancer revealed distinct rare genetic alterations. Breast Cancer Res Treat. 2008 Nov;112(1):159-64. doi: 10.1007/s10549-007-9838-7. Epub 2007 Dec 4. PubMed PMID: 18058223.

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Kleibl Z, Havranek O, Prokopcova J. Rapid detection of CAA/CAG repeat polymorphism in the AIB1 gene using DHPLC. J Biochem Biophys Methods. 2007 Apr 10;70(3):511-3. doi: 10.1016/j.jbbm.2006.11.011. Epub 2006 Dec 9. PubMed PMID: 17234271.

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Kleibl Z, Havranek O, Novotny J, Kohoutova M, Stekrova J, Matous B. [Analysis of mutation c.1100delC in the CHEK2 gene in population of patients with sporadic colorectal cancer and familial adenomatous polyposis], article in czech. Klinická Onkologie: Journal of Czech and Slovac Oncology Association. 2007; (20):224-226.