Abstract
Two new dihydrostilbenoid glycosides, named 5-(2-phenylethyl)-3-hydroxyphenol-1-O-beta-D-glucopyranoside (1) and 6-(2-phenylethyl)-2,4-dihydroxy benzoic acid-2-O-beta-D-glucopyranoside (2), together with two known compounds, were isolated from the leaves of Litsea coreana Levl.. Their structures were established on the basis of NMR spectroscopic, MS and chemical data. Biological tests revealed that 1-3 exhibited moderate anti-inflammatory activity through an inhibitory effect on TNF-alpha, IL-1 production from RAW264.7 cell line activated with lipopolysaccharides (LPS).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Cells, Cultured
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Litsea / chemistry*
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Magnetic Resonance Spectroscopy
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Mice
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Plant Leaves / chemistry
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Stilbenes / chemistry
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Stilbenes / isolation & purification*
Substances
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5-(2-phenylethyl)-3-hydroxyphenol-1-O-beta-D-glucopyranoside
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6-(2-phenylethyl)-2,4-dihydroxy benzoic acid-2-O-beta-D-glucopyranoside
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Anti-Inflammatory Agents
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Glucosides
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Stilbenes