Mycobacteria are the causative agents of tuberculosis and other serious infectious diseases that are increasingly difficult to treat due to the growing problem of antibiotic resistance. These notorious human pathogens replicate inside macrophages, a crucial cell type of our immune system. In this project a multidisciplinary team of researchers will join forces to elucidate key mechanisms underlying the complex interplay between mycobacterial virulence factors and the macrophage immune defenses. The new insights will be used to explore innovative therapeutic strategies to fight mycobacterial infections.

• crispr-cas9
• development & disease
• host-microbe interactions
• innate immunity
• intracellular pathogens
• macrophages
• tuberculosis